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High Throughput Antibody Characterization Scientist
Lawrence Livermore National Laboratory
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Posted: 25-Aug-24
Location: Livermore, California
Salary: Open
Internal Number: 3743990004900081
We have an opening for a Staff Scientist in our high throughput antibody production and characterization team. This exciting opportunity is ideal for an experienced bench scientist proficient in high throughput antibody characterization. You will be responsible for the development, implementation, and continuous optimization of automated high throughput screening platforms for the characterization of computationally designed therapeutic antibodies. Our team values scientific excellence, innovation, diverse perspectives, and collaboration. Join our dynamic team of scientists dedicated to advancing biotechnology and making a significant impact on drug discovery and development.
You will
- Contribute to developing and implementing high throughput antibody characterization assays (e.g., BLI, SPR, capillary electrophoresis, DLS, DSF)
- Contribute to developing and implementing high throughput immunoassays (e.g., AlphaLISA, MSD, Gyros, Luminex, etc.)
- Analyze and interpret experimental data, troubleshoot technical issues, and propose innovative solutions
- Collaborate with cross-functional teams to support the generation of therapeutic antibodies for various drug discovery programs
- Maintain accurate and detailed laboratory records, write technical reports, and present findings to project teams and stakeholders
- Perform other duties as assigned
- B.S. degree or equivalent experience in biotechnology, biochemistry or a related scientific discipline
- Comprehensive hands-on experience in high throughput protein characterization techniques
- Proficiency with protein analytical techniques such as SDS-PAGE, Western blotting, ELISA or advanced immunoassay platforms (e.g., AlphaLISA, MSD, Gyrolab, Luminex)
- Familiarity with protein characterization assays (e.g., SPR, BLI, capillary electrophoresis, DLS, DSF)
- Experience using automated liquid handling systems and LIMS
- Demonstrate ability to work effectively in a team environment and collaborate with colleagues from diverse scientific backgrounds
- Strong organizational skills, attention to detail, and ability to multitask in a fast-paced research environment.
Qualifications We Desire
- Design and execute experiments for high throughput antibody production and characterization using mammalian cell culture systems
- Increase efficiency of protein expression, purification, and characterization.
- Proficiency in molecular biology techniques, including gene cloning, transfection, and stable cell line generation
- Experience with antibody or other protein developability assessment.
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About Lawrence Livermore National Laboratory
For more than 60 years, the Lawrence Livermore National Laboratory has applied science and technology to make the world a safer place.Livermore’s defining responsibility is ensuring the safety, security and reliability of the nation’s nuclear deterrent. Yet LLNL’s mission is broader than stockpile stewardship, as dangers ranging from nuclear proliferation and terrorism to energy shortages and climate change threaten national security and global stability. The Laboratory’s science and engineering are being applied to achieve breakthroughs for counterterrorism and nonproliferation, defense and intelligence, energy and environmental security.
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